We describe the clinical, radiographic, and biochemical responses of a middle-aged woman with adult HPP given the recombinant PTH fragment, teriparatide (TPTD; recombinant human PTH 1–34).
The femur fracture partially mended after 2 months and then healed.
In decreasing order of severity, patients are said to experience perinatal, infantile, childhood, adult, or odontohypophosphatasia.
Actually, this nosology demarcates a remarkable continuum of HPP expressivity that is largely, but not completely (10), explained by the two inheritance patterns (autosomal-dominant or -recessive) (1) and the considerable number and variety of defects (11).
Teriparatide (TPTD) (recombinant human PTH 1–34), 20 μg, was injected sc daily in an attempt to enhance osteoblast synthesis of TNSALP.
Results: Six weeks later, all fracture pain improved, and it resolved after 4 months.
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